Waters will join guests actress Amy Adams and music act Edward Sharpe & The Magnetic Zeros.
Waters wraps up his current US dates of The Wall Live tour on Wednesday with a concert in Anaheim, California, before heading off for three dates in Mexico City.
Roger made some headline this past week by showing his support for the WikiLeaks project.
Let’s see what Waters and O’Brien talk about on Conan Wednesday night.
Roger Waters supports WikiLeaks
Roger Waters – The Wall Live tour – promo